Early communication between sectors and neighboring countries, leading to faster detection and response to disease outbreaks, is a critical step to make a difference to emerging global public health threats. Infectious diseases have a significant impact on vulnerable populations and children across the world. Outbreaks of emerging diseases pose enormous challenges to affected countries. The negative impact of disease can be reduced by facilitating effective communication and early dialogues between countries. The Southern African Centre for Infectious Disease Surveillance (SACIDS) in partnership with EAIDSNet and InSTEDD proposes to implement a 14-month project, Enhancing community-based disease outbreak detection and response in East and Southern Africa.