Challenge TB is the primary mechanism for implementing USAID's vision of a world free of TB and its global End TB Strategy.

This includes a decline in TB mortality by 35 percent and a 20 percent reduction in incidence compared to 2015 levels, and no more affected families facing catastrophic costs due to TB by 2019.

To achieve this vision, the project complements existing and planned efforts to provide global technical leadership and support to national tuberculosis programs and other in-country partners. Challenge TB also contributes to TB and HIV activities under the President's Emergency Plan for AIDS Relief (PEPFAR).