PSI began operations in Southern Sudan in January 2005, distributing Serena brand long-lasting insecticide-treated nets through the commercial sector and implementing behaviour change communication on HIV/AIDS.

Over the years, PSI operations included:

• Implementation of comprehensive hygiene, sanitation and safe water program in the cities of Juba, Yei and Wau.
• Comprehensive HIV programming that includes community outreach and capacity building of community-based organizations.
• Distribution of branded and non-branded condoms.
• Outreach and support to people living with HIV/AIDS to mitigate the impact of opportunistic infections.
• Support to County AIDS Commissions, the Ministry of Health and South Sudan AIDS Commission.