Kisiizi Hospital is rooted in the 1920’s East Africa Revival. Even though the peak of the Revival was years before the founding of the Hospital, it informed its foundation and still influences its ethos even today.

It led to strong local Christian leadership with a strong local Church in the Kigezi area, coupled with close collaboration with the Ruanda Mission, later to become reunited with Church Mission Society (CMS).

Mission Hospitals were set up in Rwanda, Burundi and Uganda, including one in Kabale, started by Dr Leonard Sharp.